Hemolytic uremic syndrome is a clinically charactgerized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure.
The precise etiology of hemolytic uremic syndrome is unknown, but has been generally accepted that hemolytic uremic syndrome represents a variable number of different causes, including infections, genetic, enviornmental, phamacological fctors,
pregnancy
and puerperium.
The pathogenesis of the hemolytic uremic syndrome is uncertain, until recently, but probably involves glomerular endothelial cell injury, and widespread intravascular platelet aggregation has been considered a crucial event in the pathogenetic
sequence.
Several combinations of treatments have been used over the years, still no form of therapy has been determined to be effective. In adults with severe disease, treatment with plasmapheresis, in addition to hemodialysis, steroids, and antiplatelet
agents,
is probably madicated.
We experienced two cases of hemolytic uremic syndrome and report with a brief review of literature.
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